Comparison of survival rates made by the 6-th and 7-th editions of TNM classification in stomach cancer patients

The available classifications of malignant tumors reflect various aspects of their growth and some biological features. The most commonly used in Ukraine is the 6-th revision of TNM classification, which differs from the previous classifications of the section "Gastric cancer", mainly staging of category N, reflecting the presence of metastases in regional lymph nodes. Transition to the 7-th classification of TNM translates a part of patients from one stage to another, there is a so-called "stage migration" phenomenon. The famous mathematical phenomenon of Will Rogers describes this transition and theoretically substantiates its objectivity. The authors tracked the migration of patients and the change in the stage mainly from the point of view of the effect of this event on the survival of patients with stomach cancer

Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center

The survival of patients with the locally advanced stage of stomach cancer (SC), who underwent various variants of preventive lymphatic nodes dissection, was considered. The survival of patients was compared with the stage and T, N indexes. Lymphadenectomy D2 were effective and increased cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo, stage III A, and in groups of patients where D2 lymphadenectomy were ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo, stage IIIB. D2 were more efficient operation in the case of tumor serosa invasion and invasion to the peritoneal cavity (SE) in the absence of multiple metastases to the regional lymph nodes (N1 according to the 7th revision of the classification - 1-2 metastatic lymph nodes), and when the tumor infiltrated the surrounding organs (SI) and the presence of multiple regional metastases, D2 lymphodissection did not gave positive results, comparising with D1

The original formula for predicting the survival of gastric cancer patients undergoing surgical treatment

The purpose of this work was to find ways to predict the survival of gastric cancer patients. The study included 221 patients who were radically operated in the abdominal department of the Odessa Regional Oncology Center from 2007 to 2013. The life expectancy of this group of patients was measured in months. From the factors given in the article, only the age of the patient, the presence and invasion in neighboring organs and the number of organs resected during the operation were those factors that had a significant impact on the prognosis. A formula was obtained for the formal evaluation of the duration of patients. The results are preliminary. Conclusions. As a result of the regression analysis, a polynomial (formula) was obtained, which can be used to predict the survival of patients who underwent surgery for gastric cancer. There is a need to create clearer gradations of survival dependencies of cancer patients from different clinical and morphological situations. A mathematical apparatus with many variables can be used to create similar models for the analysis of survival in other types of pathology

Lymph node dissection impact on long-term survival rate of gastric cancer patients in Ukraine

Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa oncological center. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60 % of patients, represented with initially hematologicaly disseminated disease. 40 % of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved

Effect of ultrasound on s. Epidermidis museum culture

The aim o f the present research project was to study the effect o f ultrasonic waves on the S. epidermidis ATCC 14990 museum culture. Materials and methods: A bibliosemantic method - for analyzing previous research based on scientific literature, electronic resources. empirical methods of scientific research (observation, comparison, measurement, experiment) - to study the effect o f ultrasound on the strain o f S. epidermidis ATCC 14990. Results: A study showed that when exposed to ultrasound for four and a h alf minutes on a culture o f microorganisms S. epidermidis in glass tubes, the number o f viable cells in the suspension decreases. Conclusions: The influence o f ultrasound on the culture o f S. epidermidis, studied in the work, showed that the selected and used parameters o f ultrasound treatment cause destructive changes in microorganisms. These changes are not fatal for the entire bacterial culture used in the study, but they have a reliable antimicrobial effect

A new case of Acute Myeloid Leukemia with semi-cryptic t(7;21)(p22;q22)

Case report of a translocation : A new case of Acute Myeloid Leukemia with semi-cryptic t(7;21)(p22;q22)

Моделирование радиосистемы на частоте 130 ГГц с использованием QPSK модуляции

Досліджена радіосистема на частоті 130 Ггц з модуляцією QPSK із застосуванням програмного пакету AWR, проаналізований вплив нелінійності на спектр сигналу. На основі отриманих результатів визначені вимоги до окремих функціональних вузлів.130 GHz radio system with QPSK modulation using AWR software is studied; influence of nonlinearity on signal spectrum is analyzed. Based on obtained results requirements for some functional units are defined.Исследована радиосистема на частоте 130 ГГц с модуляцией QPSK с применением программного пакета AWR, проанализировано влияние нелинейности на спектр сигнала. На основе полученных результатов определены требования к отдельным функциональным узлам

Department of pathological physiology

It is known that as long as antinociceptive system functions adequately pain can develop as a component of different injuries. One of the most important mechanisms of antinociception – humoral that means production of substances that block pain transmission and formation of pain feeling. Humoral mechanism includes: opioid, monoaminergic (norepinephrine, dopamine, serotonin), cholinergic, GABAergic, cannabinoid and orexin systems. Inflow of pain impulses induces production and excretion of different chemical substances which forms analgesia in different levels of pain system

The Design Technique for Power Management Unit of the Tag IC for Radio Frequency Identification of Critical Infrastructure Objects

The ultra-high frequency (UHF) tag IC’s main part of the power management unit (PMU) design technique is presented. The technique is a step-by-step algorithm for designing a PMU and consists of five interrelated stages. At the first stage, the requirements for the parameters of the PMU (output voltage, output DC power, efficiency, output capacitor capacity) and the Q-factor of the tag analog front-end are determinates. At the second stage, the design of an electrical circuit of a voltage multiplier (VM) is carried out. VM is required to convert the voltage of the input radio frequency (RF) signal into an DC voltage. During the third stage, the design of the electrical circuit of the DC voltage limiter is carried out, which is necessary to reduce the output voltage of VM to a safe level. The result of stage 4 is an electrical circuit of surge protection designed to provide the required level of immunity of the tag IC to the effects of electrostatic discharge and a high-power RF signal. As part of the final stage, the evaluation and alignment with the required Q-factor value of the tag IC analog front-end is carried out. The proposed technique can be used for the development of domestic UHF tag ICs (ISO 18000-6C, GJB 7377.1, etc.) based on CMOS technological processes, including ICs designed for radio frequency identification of critical infrastructure objects. Using the presented technique, the design of a PMU with an estimated efficiency value of 70%, an estimated Q-factor of the analog front-end of less than 15 at an RF input signal power of -12.7 dBm was performed

Deformation properties of mastoid area skin

The mechanical properties of the skin have been studied in vivo and in vitro using various test methods. It has been found that with age, the skin undergoes considerably less deformation at the same voltage, which is probably due to the change of collagen and elastin nets. Two-dimensional biomechanical behavior and the content of collagen in human skin samples from different areas of topical localization were studied. The minimum and maximum reduction axes were determined after removal and their connection with Langer’s lines. The experimental equipment was designed to keep the geometry and measure loads acting perpendicular to the circle of skin samples. Using in vivo geometry of samples as a base, various deformations were applied. After the voltage relaxation, the final values of the voltage were taken and compared with the deformations. It was found that the axes of maximum and minimum stress do not coin-cide with the Langer’s lines, and rotated 10°. This article describes the structure of the mastoid area skin. After the objective morphological studies, we came to the conclusion that during the surgery on the mastoid region, namely cosmetic otoplasty and lower rhytidectomy, the length of stretching skin-fat grafts must be taken into account. No visible lesions were found in their deformation in the range of 5-10 mm. This is the optimal minimum and maximum limit of biomechanical parameters in such interventions. Patho-logical changes primarily in the form of balloon degeneration were observed at the 15-20 mm flap tension, indicating a greater likelihood of necrosis in the postoperative period. Deformation of the skin-fat grafts of 25 mm leads to irreversible changes and hemodynamic disorders, thus flap stretching within these parameters is unacceptable. The aim of this study was to investigate the morphological features of skin-fatty grafts of mastoid area at various stages of deformation. In the experiment we used 30 skin-fatty grafts taken from the patients with roughness during cosmetic otoplasty. These pieces were elongated at 5, 10, 15, 20, 25 mm respectively; they were colored by hematoxylin-eosin as well as van Gieson stai